Versatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N(2)-Alkylguanine Adducts

In contrast to replicative DNA polymerases, Sulfolobus solfataricus Dpo4 showed a limited decrease in catalytic efficiency (k(cat)/K(m)) for insertion of dCTP opposite a series of N(2)-alkylguanine templates of increasing size from (methyl (Me) to (9-anthracenyl)-Me (Anth)). Fidelity was maintained...

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Detalhes bibliográficos
Main Authors: Zhang, Huidong, Eoff, Robert L., Kozekov, Ivan D., Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636699/
https://ncbi.nlm.nih.gov/pubmed/19059910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807778200
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