14-3-3:Shc Scaffolds Integrate Phosphoserine and Phosphotyrosine Signaling to Regulate Phosphatidylinositol 3-Kinase Activation and Cell Survival

Integrated cascades of protein tyrosine and serine/threonine phosphorylation play essential roles in transducing signals in response to growth factors and cytokines. How adaptor or scaffold proteins assemble signaling complexes through both phosphotyrosine and phosphoserine/threonine residues to reg...

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Autors principals: Barry, Emma F., Felquer, Fernando A., Powell, Jason A., Biggs, Lisa, Stomski, Frank C., Urbani, Andrea, Ramshaw, Hayley, Hoffmann, Peter, Wilce, Matthew C., Grimbaldeston, Michele A., Lopez, Angel F., Guthridge, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673277/
https://ncbi.nlm.nih.gov/pubmed/19218246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807637200
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