Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

The Shc adaptor protein contains two phosphotyrosine [Tyr(P)]binding modules--an N-terminal Tyr(P) binding (PTB) domain and a C-terminal Src homology 2 (SH2) domain. We have compared the ability of the Shc PTB domain to bind the receptors for nerve growth factor and insulin, both of which contain ju...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	van der Geer, P, Wiley, S, Gish, G D, Lai, V K, Stephens, R, White, M F, Kaplan, D, Pawson, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577769/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.963
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