Genetic Ablation of Caveolin-1 Drives Estrogen-Hypersensitivity and the Development of DCIS-Like Mammary Lesions

Caveolin-1 (Cav-1) loss-of-function mutations are exclusively associated with estrogen receptor-positive (ER(+)) human breast cancers. To dissect the role of Cav-1 loss-of-function in the pathogenesis of human breast cancers, we used Cav-1(−/−) null mice as a model system. First, we demonstrated tha...

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Main Authors: Mercier, Isabelle, Casimiro, Mathew C., Zhou, Jie, Wang, Chenguang, Plymire, Christopher, Bryant, Kelly G., Daumer, Kristin M., Sotgia, Federica, Bonuccelli, Gloria, Witkiewicz, Agnieszka K., Lin, Justin, Hong Tran, Thai, Milliman, Janet, Frank, Philippe G., Jasmin, Jean-François, Rui, Hallgeir, Pestell, Richard G., Lisanti, Michael P.
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671351/
https://ncbi.nlm.nih.gov/pubmed/19342371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080882
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