Stromal and Epithelial Caveolin-1 Both Confer a Protective Effect Against Mammary Hyperplasia and Tumorigenesis : Caveolin-1 Antagonizes Cyclin D1 Function in Mammary Epithelial Cells

Here, we investigate the role of caveolin-1 (Cav-1) in breast cancer onset and progression, with a focus on epithelial-stromal interactions, ie, the tumor microenvironment. Cav-1 is highly expressed in adipocytes and is abundant in mammary fat pads (stroma), but it remains unknown whether loss of Ca...

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Detalhes bibliográficos
Main Authors: Williams, Terence M., Sotgia, Federica, Lee, Hyangkyu, Hassan, Ghada, Di Vizio, Dolores, Bonuccelli, Gloria, Capozza, Franco, Mercier, Isabelle, Rui, Hallgeir, Pestell, Richard G., Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780215/
https://ncbi.nlm.nih.gov/pubmed/17071600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060590
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