Caveolin-1 Mutations (P132L and Null) and the Pathogenesis of Breast Cancer : Caveolin-1 (P132L) Behaves in a Dominant-Negative Manner and Caveolin-1 (−/−) Null Mice Show Mammary Epithelial Cell Hyperplasia

Caveolin-1 (Cav-1) is the principal structural protein of caveolae membranes that are found in most cells types, including mammary epithelial cells. Recently, we mapped the human CAV1 gene to a suspected tumor suppressor locus (7q31.1/D7S522) that is deleted in a variety of human cancers, as well as...

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Hlavní autoři: Lee, Hyangkyu, Park, David S., Razani, Babak, Russell, Robert G., Pestell, Richard G., Lisanti, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2002
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867297/
https://ncbi.nlm.nih.gov/pubmed/12368209
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