Caveolin-1 (P132L), a Common Breast Cancer Mutation, Confers Mammary Cell Invasiveness and Defines a Novel Stem Cell/Metastasis-Associated Gene Signature

Here we used the Met-1 cell line in an orthotopic transplantation model in FVB/N mice to dissect the role of the Cav-1(P132L) mutation in human breast cancer. Identical experiments were performed in parallel with wild-type Cav-1. Cav-1(P132L) up-regulated the expression of estrogen receptor-α as pre...

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Detalhes bibliográficos
Main Authors: Bonuccelli, Gloria, Casimiro, Mathew C., Sotgia, Federica, Wang, Chenguang, Liu, Manran, Katiyar, Sanjay, Zhou, Jie, Dew, Elliott, Capozza, Franco, Daumer, Kristin M., Minetti, Carlo, Milliman, Janet N., Alpy, Fabien, Rio, Marie-Christine, Tomasetto, Catherine, Mercier, Isabelle, Flomenberg, Neal, Frank, Philippe G., Pestell, Richard G., Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671254/
https://ncbi.nlm.nih.gov/pubmed/19395651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080648
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