Genetic Ablation of Caveolin-1 Drives Estrogen-Hypersensitivity and the Development of DCIS-Like Mammary Lesions

Caveolin-1 (Cav-1) loss-of-function mutations are exclusively associated with estrogen receptor-positive (ER(+)) human breast cancers. To dissect the role of Cav-1 loss-of-function in the pathogenesis of human breast cancers, we used Cav-1(−/−) null mice as a model system. First, we demonstrated tha...

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Hauptverfasser: Mercier, Isabelle, Casimiro, Mathew C., Zhou, Jie, Wang, Chenguang, Plymire, Christopher, Bryant, Kelly G., Daumer, Kristin M., Sotgia, Federica, Bonuccelli, Gloria, Witkiewicz, Agnieszka K., Lin, Justin, Hong Tran, Thai, Milliman, Janet, Frank, Philippe G., Jasmin, Jean-François, Rui, Hallgeir, Pestell, Richard G., Lisanti, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671351/
https://ncbi.nlm.nih.gov/pubmed/19342371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080882
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