Intranigral lentiviral delivery of dominant negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats

Neuroinflammatory processes have been implicated in the progressive loss of ventral midbrain dopaminergic neurons that give rise to Parkinson’s disease, a late-onset movement disorder that affects 2% of the population over age 70. Previously, we demonstrated that inhibition of the pro-inflammatory c...

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Hauptverfasser: McCoy, Melissa K., Ruhn, Kelly A., Martinez, Terina N., McAlpine, Fiona E., Blesch, Armin, Tansey, Malu G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670754/
https://ncbi.nlm.nih.gov/pubmed/18628756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.146
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