Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer's disease (AD). Elevated levels of the pro-inflammatory cytokine Tumor Necrosis Factor (TNF) have been reported in serum and post-mortem brains of patients wi...

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Autors principals: McAlpine, Fiona E., Lee, Jae-Kyung, Harms, Ashley S., Ruhn, Kelly A., Blurton-Jones, Mathew, Hong, John, Das, Pritam, Golde, Todd E., LaFerla, Frank M., Oddo, Salvatore, Blesch, Armin, Tansey, Malú G.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948857/
https://ncbi.nlm.nih.gov/pubmed/19320056
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