Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

Parkinson's disease (PD) is a progressive neurodegenerative disorder typified by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Recent evidence indicates that neuroinflammation may play a critical role in the pathogenesis of PD, particularly tumor necrosis f...

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Detalhes bibliográficos
Main Authors: Harms, Ashley S, Barnum, Christopher J, Ruhn, Kelly A, Varghese, Steve, Treviño, Isaac, Blesch, Armin, Tansey, Malú G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017447/
https://ncbi.nlm.nih.gov/pubmed/20959812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.217
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