AAV-Dominant Negative Tumor Necrosis Factor (DN-TNF) Gene Transfer to the Striatum Does Not Rescue Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease

CNS inflammation is a hallmark of neurodegenerative disease, and recent studies suggest that the inflammatory response may contribute to neuronal demise. In particular, increased tumor necrosis factor (TNF) signaling is implicated in the pathology of both Parkinson's disease (PD) and Alzheimer&...

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Autori principali: Alto, Laura Taylor, Chen, Xi, Ruhn, Kelly A., Treviño, Isaac, Tansey, Malú G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019512/
https://ncbi.nlm.nih.gov/pubmed/24824433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096544
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