Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease

The mechanisms that trigger or contribute to loss of dopaminergic (DA) neurons in Parkinson's disease (PD) remain unclear and controversial. Elevated levels of tumor necrosis factor (TNF) in CSF and postmortem brains of PD patients and animal models of PD implicate this proinflammatory cytokine...

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Main Authors: McCoy, Melissa K., Martinez, Terina N., Ruhn, Kelly A., Szymkowski, David E., Smith, Christine G., Botterman, Barry R., Tansey, Keith E., Tansey, Malú G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707118/
https://ncbi.nlm.nih.gov/pubmed/16971520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1504-06.2006
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