Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons

BACKGROUND: Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson’s disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF)...

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Detalhes bibliográficos
Main Authors: Martinez, Terina N, Chen, Xi, Bandyopadhyay, Sibali, Merrill, Alfred H, Tansey, Malú G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472284/
https://ncbi.nlm.nih.gov/pubmed/22973882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-45
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