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Transition States of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases
Orotate phosphoribosyltransferases (OPRT) catalyze the formation of orotidine 5′-monophosphate (OMP) from α-D-phosphoribosylpyrophosphate (PRPP) and orotate, an essential step in the de novo biosynthesis of pyrimidines. Pyrimidine de novo biosynthesis is required in Plasmodium falciparum, thus OPRT...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669657/ https://ncbi.nlm.nih.gov/pubmed/19292447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808346y |
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