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The BRC Repeats of BRCA2 Modulate the DNA Binding Selectivity of RAD51
The breast cancer susceptibility protein, BRCA2, is essential for recombinational DNA repair. BRCA2 delivers RAD51 to double-stranded DNA (dsDNA) breaks through interaction with eight conserved, ~35 amino acid motifs, the BRC repeats. Here we show that the solitary BRC4 promotes assembly of RAD51 on...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2669112/ https://ncbi.nlm.nih.gov/pubmed/19303847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.02.019 |
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