The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1–8])). Here, we show that BRCA2([BRC1–8]) exerts...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Shivji, Mahmud K. K., Mukund, Shreyas R., Rajendra, Eeson, Chen, Shaoxia, Short, Judith M., Savill, Jane, Klenerman, David, Venkitaraman, Ashok R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714763/
https://ncbi.nlm.nih.gov/pubmed/19628690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906208106
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge