The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability. BRCA2 binds to RAD51 through 8 conserved BRC repeat motifs dispersed in an 1127-residue region (BRCA2([BRC1–8])). Here, we show that BRCA2([BRC1–8]) exerts...

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Detalhes bibliográficos
Main Authors: Shivji, Mahmud K. K., Mukund, Shreyas R., Rajendra, Eeson, Chen, Shaoxia, Short, Judith M., Savill, Jane, Klenerman, David, Venkitaraman, Ashok R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714763/
https://ncbi.nlm.nih.gov/pubmed/19628690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906208106
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