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High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy

Homologous DNA recombination (HR) by the RAD51 recombinase enables error-free DNA break repair. To execute HR, RAD51 first forms a presynaptic filament on single-stranded (ss) DNA, which catalyses pairing with homologous double-stranded (ds) DNA. Here, we report a structure for the presynaptic human...

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Pubblicato in:Nucleic Acids Res
Autori principali: Short, Judith M., Liu, Yang, Chen, Shaoxia, Soni, Neelesh, Madhusudhan, Mallur S., Shivji, Mahmud K.K., Venkitaraman, Ashok R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100573/
https://ncbi.nlm.nih.gov/pubmed/27596592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw783
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