The BRC Repeats of BRCA2 Modulate the DNA Binding Selectivity of RAD51

The breast cancer susceptibility protein, BRCA2, is essential for recombinational DNA repair. BRCA2 delivers RAD51 to double-stranded DNA (dsDNA) breaks through interaction with eight conserved, ~35 amino acid motifs, the BRC repeats. Here we show that the solitary BRC4 promotes assembly of RAD51 on...

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Main Authors: Carreira, Aura, Hilario, Jovencio, Amitani, Ichiro, Baskin, Ronald J., Shivji, Mahmud K.K., Venkitaraman, Ashok R., C.Kowalczykowski, Stephen
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669112/
https://ncbi.nlm.nih.gov/pubmed/19303847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.02.019
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