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A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
Human BRCA2, a breast and ovarian cancer suppressor, binds to the DNA recombinase RAD51 through eight conserved BRC repeats, motifs of ∼30 residues, dispersed across a large region of the protein. BRCA2 is essential for homologous recombination in vivo, but isolated BRC repeat peptides can prevent t...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1557805/ https://ncbi.nlm.nih.gov/pubmed/16914443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl505 |
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