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Interaction with the BRCA2 C-terminus Protects RAD51–DNA Filaments from Disassembly by BRC Repeats

BRCA2 is essential for DNA repair by homologous recombination via its interaction with RAD51, mediated by short motifs in the middle and at the C-terminus of its sequence. Here we report that a conserved 36-residue exon 27 sequence of human BRCA2 (BRCA2(Exon 27)) interacts with RAD51 through the spe...

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Autori principali: Davies, Owen Richard, Pellegrini, Luca
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096194/
https://ncbi.nlm.nih.gov/pubmed/17515903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1251
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