Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity

BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is crucial for understanding homologous recombination and how patient-derived mutations impact future cancer risk. Eight centrall...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Chatterjee, Gouri, Jimenez-Sainz, Judit, Presti, Thomas, Nguyen, Tiffany, Jensen, Ryan B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Genome Integrity, Repair and Replication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914107/
https://ncbi.nlm.nih.gov/pubmed/27084934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw242
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