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Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
BRCA2 is a multi-faceted protein critical for the proper regulation of homology-directed repair of DNA double-strand breaks. Elucidating the mechanistic features of BRCA2 is crucial for understanding homologous recombination and how patient-derived mutations impact future cancer risk. Eight centrall...
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| Udgivet i: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914107/ https://ncbi.nlm.nih.gov/pubmed/27084934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw242 |
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