The BRC Repeats of BRCA2 Modulate the DNA Binding Selectivity of RAD51

The breast cancer susceptibility protein, BRCA2, is essential for recombinational DNA repair. BRCA2 delivers RAD51 to double-stranded DNA (dsDNA) breaks through interaction with eight conserved, ~35 amino acid motifs, the BRC repeats. Here we show that the solitary BRC4 promotes assembly of RAD51 on...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Carreira, Aura, Hilario, Jovencio, Amitani, Ichiro, Baskin, Ronald J., Shivji, Mahmud K.K., Venkitaraman, Ashok R., C.Kowalczykowski, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669112/
https://ncbi.nlm.nih.gov/pubmed/19303847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.02.019
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares