β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

β-Arrestins are multifunctional adaptors that mediate the desensitization, internalization, and some signaling functions of seven-transmembrane receptors (7TMRs). Agonist-stimulated ubiquitination of β-arrestin2 mediated by the E3 ubiquitin ligase Mdm2 is critical for rapid β(2)-adrenergic receptor...

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Main Authors: Shenoy, Sudha K., Modi, Aalok S., Shukla, Arun K., Xiao, Kunhong, Berthouze, Magali, Ahn, Seungkirl, Wilkinson, Keith D., Miller, William E., Lefkowitz, Robert J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667797/
https://ncbi.nlm.nih.gov/pubmed/19363159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901083106
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