The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

γ-Retroviral vectors (γRVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and viral integration site selection (ISS) to oncogenesis using an in vivo genotoxicity assay based on transplantation o...

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Bibliografski detalji
Glavni autori: Montini, Eugenio, Cesana, Daniela, Schmidt, Manfred, Sanvito, Francesca, Bartholomae, Cynthia C., Ranzani, Marco, Benedicenti, Fabrizio, Sergi, Lucia Sergi, Ambrosi, Alessandro, Ponzoni, Maurilio, Doglioni, Claudio, Di Serio, Clelia, von Kalle, Christof, Naldini, Luigi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2009
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662564/
https://ncbi.nlm.nih.gov/pubmed/19307726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37630
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