The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

γ-Retroviral vectors (γRVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and viral integration site selection (ISS) to oncogenesis using an in vivo genotoxicity assay based on transplantation o...

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Détails bibliographiques
Auteurs principaux: Montini, Eugenio, Cesana, Daniela, Schmidt, Manfred, Sanvito, Francesca, Bartholomae, Cynthia C., Ranzani, Marco, Benedicenti, Fabrizio, Sergi, Lucia Sergi, Ambrosi, Alessandro, Ponzoni, Maurilio, Doglioni, Claudio, Di Serio, Clelia, von Kalle, Christof, Naldini, Luigi
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662564/
https://ncbi.nlm.nih.gov/pubmed/19307726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37630
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