The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

γ-Retroviral vectors (γRVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and viral integration site selection (ISS) to oncogenesis using an in vivo genotoxicity assay based on transplantation o...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Montini, Eugenio, Cesana, Daniela, Schmidt, Manfred, Sanvito, Francesca, Bartholomae, Cynthia C., Ranzani, Marco, Benedicenti, Fabrizio, Sergi, Lucia Sergi, Ambrosi, Alessandro, Ponzoni, Maurilio, Doglioni, Claudio, Di Serio, Clelia, von Kalle, Christof, Naldini, Luigi
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2009
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662564/
https://ncbi.nlm.nih.gov/pubmed/19307726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37630
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