Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

The analysis of genomic distribution of retroviral vectors is a powerful tool to monitor ‘vector-on-host’ effects in gene therapy (GT) trials but also provides crucial information about ‘host-on-vector’ influences based on the target cell genetic and epigenetic state. We had the unique occasion to c...

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Detalhes bibliográficos
Main Authors: Biasco, Luca, Ambrosi, Alessandro, Pellin, Danilo, Bartholomae, Cynthia, Brigida, Immacolata, Roncarolo, Maria Grazia, Di Serio, Clelia, von Kalle, Christof, Schmidt, Manfred, Aiuti, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060339/
https://ncbi.nlm.nih.gov/pubmed/21243617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201000108
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