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Estimated Comparative Integration Hotspots Identify Different Behaviors of Retroviral Gene Transfer Vectors
Integration of retroviral vectors in the human genome follows non random patterns that favor insertional deregulation of gene expression and may cause risks of insertional mutagenesis when used in clinical gene therapy. Understanding how viral vectors integrate into the human genome is a key issue i...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228801/ https://ncbi.nlm.nih.gov/pubmed/22144885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002292 |
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