Estimated Comparative Integration Hotspots Identify Different Behaviors of Retroviral Gene Transfer Vectors

Integration of retroviral vectors in the human genome follows non random patterns that favor insertional deregulation of gene expression and may cause risks of insertional mutagenesis when used in clinical gene therapy. Understanding how viral vectors integrate into the human genome is a key issue i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ambrosi, Alessandro, Glad, Ingrid K., Pellin, Danilo, Cattoglio, Claudia, Mavilio, Fulvio, Di Serio, Clelia, Frigessi, Arnoldo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2011
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228801/
https://ncbi.nlm.nih.gov/pubmed/22144885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002292
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