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Comparison of Raltegravir and Elvitagravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants

HIV-1 integrase (IN) is the molecular target of the newly approved anti-AIDS drug raltegravir (MK-0518, Isentress(®))) while elvitegravir (GS-9137, JTK-303) is in clinical trials. The aims of the present study were: 1/ to investigate and compare the effects of raltegravir and elvitegravir on the thr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Marinello, Jessica, Marchand, Christophe, Mott, Bryan, Bain, Anjali, Thomas, Craig J., Pommier, Yves
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660605/
https://ncbi.nlm.nih.gov/pubmed/18702518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800791q
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