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Comparison of Raltegravir and Elvitagravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants
HIV-1 integrase (IN) is the molecular target of the newly approved anti-AIDS drug raltegravir (MK-0518, Isentress(®))) while elvitegravir (GS-9137, JTK-303) is in clinical trials. The aims of the present study were: 1/ to investigate and compare the effects of raltegravir and elvitegravir on the thr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660605/ https://ncbi.nlm.nih.gov/pubmed/18702518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800791q |
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