Airway and lung pathology due to mucosal surface dehydration in β-Epithelial Na(+) Channel-overexpressing mice: role of TNFα and IL-4Rα signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment

Overexpression of the epithelial Na(+) channel β subunit (Scnn1b gene, βENaC protein) in transgenic (Tg) mouse airways dehydrates mucosal surfaces, producing mucus obstruction, inflammation, and neonatal mortality. Airway inflammation includes macrophage activation, neutrophil and eosinophil recruit...

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Autori principali: Livraghi, Alessandra, Grubb, Barbara R., Hudson, Elizabeth J., Wilkinson, Kristen J., Sheehan, John K., Mall, Marcus A., O'Neal, Wanda K., Boucher, Richard C., Randell, Scott H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659461/
https://ncbi.nlm.nih.gov/pubmed/19299736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802557
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