Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction

Mucus clearance is an important airway innate defense mechanism. Airway-targeted overexpression of the epithelial Na(+) channel β-subunit [encoded by sodium channel nonvoltage gated 1, beta subunit (Scnn1b)] in mice [Scnn1b-transgenic (Tg) mice] increases transepithelial Na(+) absorption and dehydra...

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Autors principals: Livraghi-Butrico, Alessandra, Grubb, Barbara R., Kelly, Elizabeth J., Wilkinson, Kristen J., Yang, Huifang, Geiser, Marianne, Randell, Scott H., Boucher, Richard C., O'Neal, Wanda K.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339860/
https://ncbi.nlm.nih.gov/pubmed/22395316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00185.2011
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