Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses

Resident immune cells (e.g., macrophages [MΦs]) and airway mucus clearance both contribute to a healthy lung environment. To investigate interactions between pulmonary MΦ function and defective mucus clearance, a genetic model of lysozyme M (LysM) promoter–mediated MΦ depletion was generated, charac...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Saini, Yogesh, Wilkinson, Kristen J., Terrell, Kristy A., Burns, Kimberlie A., Livraghi-Butrico, Alessandra, Doerschuk, Claire M., O’Neal, Wanda K., Boucher, Richard C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821038/
https://ncbi.nlm.nih.gov/pubmed/26121027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0111OC
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