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Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases. In Scnn1b-transgenic (Scnn1b-Tg(+)) mice, airway-targeted overexpression of the epithelial Na(+) channel β subunit causes airway surface dehydration, which results in mucus stasis and inflammation....
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377774/ https://ncbi.nlm.nih.gov/pubmed/22419116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.17 |
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