Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation

It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases. In Scnn1b-transgenic (Scnn1b-Tg(+)) mice, airway-targeted overexpression of the epithelial Na(+) channel β subunit causes airway surface dehydration, which results in mucus stasis and inflammation....

Full description

Saved in:
Bibliographic Details
Main Authors: Livraghi-Butrico, Alessandra, Kelly, E. Jane, Klem, Erich R., Dang, Hong, Wolfgang, Matthew C., Boucher, Richard C., Randell, Scott H., O’Neal, Wanda K.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377774/
https://ncbi.nlm.nih.gov/pubmed/22419116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.17
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items