Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation

It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung diseases. In Scnn1b-transgenic (Scnn1b-Tg(+)) mice, airway-targeted overexpression of the epithelial Na(+) channel β subunit causes airway surface dehydration, which results in mucus stasis and inflammation....

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Main Authors: Livraghi-Butrico, Alessandra, Kelly, E. Jane, Klem, Erich R., Dang, Hong, Wolfgang, Matthew C., Boucher, Richard C., Randell, Scott H., O’Neal, Wanda K.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377774/
https://ncbi.nlm.nih.gov/pubmed/22419116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.17
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