Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways

The epithelial Na(+) channel (ENaC) regulates airway surface hydration. In mouse airways, ENaC is composed of three subunits, α, β, and γ, which are differentially expressed (α > β > γ). Airway-targeted overexpression of the β subunit results in Na(+) hyperabsorption, causing airway surface de...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Livraghi-Butrico, Alessandra, Wilkinson, Kristen J., Volmer, Allison S., Gilmore, Rodney C., Rogers, Troy D., Caldwell, Ray A., Burns, Kimberlie A., Esther, Charles R, Mall, Marcus A., Boucher, Richard C., O’Neal, Wanda K., Grubb, Barbara R.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866504/
https://ncbi.nlm.nih.gov/pubmed/29074490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00382.2017
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