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Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways

The epithelial Na(+) channel (ENaC) regulates airway surface hydration. In mouse airways, ENaC is composed of three subunits, α, β, and γ, which are differentially expressed (α > β > γ). Airway-targeted overexpression of the β subunit results in Na(+) hyperabsorption, causing airway surface de...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Livraghi-Butrico, Alessandra, Wilkinson, Kristen J., Volmer, Allison S., Gilmore, Rodney C., Rogers, Troy D., Caldwell, Ray A., Burns, Kimberlie A., Esther, Charles R, Mall, Marcus A., Boucher, Richard C., O’Neal, Wanda K., Grubb, Barbara R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866504/
https://ncbi.nlm.nih.gov/pubmed/29074490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00382.2017
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