A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because the...

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Main Authors: Granville, Courtney A., Memmott, Regan M., Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, LoPiccolo, Jaclyn, Foley, Jason, Liewehr, David J., Steinberg, Seth M., Fowler, Daniel H., Hollander, M. Christine, Dennis, Phillip A.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659439/
https://ncbi.nlm.nih.gov/pubmed/19330036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005061
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