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A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because the...

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Detalhes bibliográficos
Main Authors: Granville, Courtney A., Memmott, Regan M., Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, LoPiccolo, Jaclyn, Foley, Jason, Liewehr, David J., Steinberg, Seth M., Fowler, Daniel H., Hollander, M. Christine, Dennis, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659439/
https://ncbi.nlm.nih.gov/pubmed/19330036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005061
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