A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because the...

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Main Authors: Granville, Courtney A., Memmott, Regan M., Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, LoPiccolo, Jaclyn, Foley, Jason, Liewehr, David J., Steinberg, Seth M., Fowler, Daniel H., Hollander, M. Christine, Dennis, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659439/
https://ncbi.nlm.nih.gov/pubmed/19330036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005061
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