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A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis
BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because the...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659439/ https://ncbi.nlm.nih.gov/pubmed/19330036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005061 |
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