A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because the...

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Autores principales: Granville, Courtney A., Memmott, Regan M., Balogh, Andria, Mariotti, Jacopo, Kawabata, Shigeru, Han, Wei, LoPiccolo, Jaclyn, Foley, Jason, Liewehr, David J., Steinberg, Seth M., Fowler, Daniel H., Hollander, M. Christine, Dennis, Phillip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659439/
https://ncbi.nlm.nih.gov/pubmed/19330036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005061
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