The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells

Amyloid fibril formation of mutant transthyretin (TTR) that causes familial amyloid polyneuropathy occurs in the extracellular space. Thus, secretion of TTR variants contributes to the pathogenesis of amyloidosis. However, the molecular mechanisms underlying the endoplasmic reticulum (ER) exit or re...

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Detaylı Bibliyografya
Asıl Yazarlar: Susuki, Seiko, Sato, Takashi, Miyata, Masanori, Momohara, Mamiko, Suico, Mary Ann, Shuto, Tsuyoshi, Ando, Yukio, Kai, Hirofumi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659189/
https://ncbi.nlm.nih.gov/pubmed/19188365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809354200
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