The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells

Amyloid fibril formation of mutant transthyretin (TTR) that causes familial amyloid polyneuropathy occurs in the extracellular space. Thus, secretion of TTR variants contributes to the pathogenesis of amyloidosis. However, the molecular mechanisms underlying the endoplasmic reticulum (ER) exit or re...

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Autors principals: Susuki, Seiko, Sato, Takashi, Miyata, Masanori, Momohara, Mamiko, Suico, Mary Ann, Shuto, Tsuyoshi, Ando, Yukio, Kai, Hirofumi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659189/
https://ncbi.nlm.nih.gov/pubmed/19188365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809354200
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