The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells

Amyloid fibril formation of mutant transthyretin (TTR) that causes familial amyloid polyneuropathy occurs in the extracellular space. Thus, secretion of TTR variants contributes to the pathogenesis of amyloidosis. However, the molecular mechanisms underlying the endoplasmic reticulum (ER) exit or re...

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Hlavní autoři: Susuki, Seiko, Sato, Takashi, Miyata, Masanori, Momohara, Mamiko, Suico, Mary Ann, Shuto, Tsuyoshi, Ando, Yukio, Kai, Hirofumi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659189/
https://ncbi.nlm.nih.gov/pubmed/19188365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809354200
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