The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells

Amyloid fibril formation of mutant transthyretin (TTR) that causes familial amyloid polyneuropathy occurs in the extracellular space. Thus, secretion of TTR variants contributes to the pathogenesis of amyloidosis. However, the molecular mechanisms underlying the endoplasmic reticulum (ER) exit or re...

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Detalhes bibliográficos
Main Authors: Susuki, Seiko, Sato, Takashi, Miyata, Masanori, Momohara, Mamiko, Suico, Mary Ann, Shuto, Tsuyoshi, Ando, Yukio, Kai, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659189/
https://ncbi.nlm.nih.gov/pubmed/19188365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809354200
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