Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell

The secretion of transthyretin (TTR) variants contributes to the pathogenesis of amyloidosis because they form aggregates in the extracellular environment. However, the mechanism of how TTR variants pass the quality control system in the endoplasmic reticulum (ER) has not yet been elucidated. We inv...

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Main Authors: Sato, Takashi, Susuki, Seiko, Suico, Mary Ann, Miyata, Masanori, Ando, Yukio, Mizuguchi, Mineyuki, Takeuchi, Makoto, Dobashi, Mizuki, Shuto, Tsuyoshi, Kai, Hirofumi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868898/
https://ncbi.nlm.nih.gov/pubmed/17431395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601685
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