Novel Determinants of Epithelial Sodium Channel Gating within Extracellular Thumb Domains

Activity of the epithelial Na(+) channel (ENaC) is modulated by Na(+) self-inhibition, an allosteric down-regulation of channel open probability by extracellular Na(+). We searched for determinants of Na(+) self-inhibition by analyzing changes in this inhibitory response resulting from specific muta...

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Main Authors: Maarouf, Ahmad B., Sheng, Nan, Chen, Jingxin, Winarski, Katie L., Okumura, Sora, Carattino, Marcelo D., Boyd, Cary R., Kleyman, Thomas R., Sheng, Shaohu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Membrane Transport, Structure, Function, and Biogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658069/
https://ncbi.nlm.nih.gov/pubmed/19158091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807060200
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