PKC-β1 Mediates Glucose-Induced Akt Activation and TGF-β1 Upregulation in Mesangial Cells

Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in mesangial cells through transactivation of the EGF receptor (EGFR). In addition, in renal tubular cells, glucose-induced secretion of TGF-β...

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Autors principals: Wu, Dongcheng, Peng, Fangfang, Zhang, Baifang, Ingram, Alistair J., Kelly, Darren J., Gilbert, Richard E., Gao, Bo, Krepinsky, Joan C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2009
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653673/
https://ncbi.nlm.nih.gov/pubmed/19211711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008040445
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