SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis

Angiotensin II is an important mediator of CKD of diverse etiology. A common pathologic feature of CKD is glomerular fibrosis, a central mediator of which is the profibrotic cytokine TGF-β. The mechanisms underlying the induction of TGF-β and matrix by angiotensin II are not completely understood. R...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Wang, Tony N., Chen, Xing, Li, Renzhong, Gao, Bo, Mohammed-Ali, Zahraa, Lu, Chao, Yum, Victoria, Dickhout, Jeffrey G., Krepinsky, Joan C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2015
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520156/
https://ncbi.nlm.nih.gov/pubmed/25398788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013121332
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