TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells

Increased intraglomerular pressure is an important pathogenic determinant of kidney fibrosis in the progression of chronic kidney disease, and can be modeled by exposing glomerular mesangial cells (MC) to mechanical stretch. MC produce extracellular matrix and profibrotic cytokines, including connec...

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Detalhes bibliográficos
Main Authors: Chen, Guang, Chen, Xing, Sukumar, Aravin, Gao, Bo, Curley, Jessica, Schnaper, H. William, Ingram, Alistair J., Krepinsky, Joan C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744028/
https://ncbi.nlm.nih.gov/pubmed/23781022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.126714
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