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β-Catenin Causes Renal Dysplasia via Upregulation of Tgfβ2 and Dkk1
Renal dysplasia, defined by defective ureteric branching morphogenesis and nephrogenesis, is the major cause of renal failure in infants and children. Here, we define a pathogenic role for a β-catenin–activated genetic pathway in murine renal dysplasia. Stabilization of β-catenin in the ureteric cel...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3065227/ https://ncbi.nlm.nih.gov/pubmed/21436291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010050562 |
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