Quantitative High Throughput Screening Using a Live Cell cAMP Assay Identifies Small Molecule Agonists of the TSH Receptor

The thyroid stimulating hormone receptor (TSHR) belongs to the glycoprotein hormone receptor subfamily of seven-transmembrane spanning receptors. TSHR is expressed in thyroid follicular cells and is activated by TSH, which regulates growth and function of these cells. Recombinant TSH is used in diag...

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Hlavní autoři: Titus, Steve, Neumann, Susanne, Zheng, Wei, Southall, Noel, Michael, Sam, Klumpp, Carleen, Yasgar, Adam, Shinn, Paul, Thomas, Craig J., Inglese, Jim, Gershengorn, Marvin C., Austin, Christopher P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653065/
https://ncbi.nlm.nih.gov/pubmed/18216391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057107313786
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